What Is Palbociclib?
Palbociclib is a cancer medicine that interferes with the growth and spread of cancer cells in the body.
Palbociclib is used in men and women to treat certain types of advanced breast cancer that has spread to other parts of the body.
In postmenopausal women, palbociclib is given in combination with a hormonal medicine called letrozole (Femara). In others, palbociclib is given together with fulvestrant (Faslodex).
Palbociclib may also be used for purposes not listed in this medication guide.
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
You should not use palbociclib if you are allergic to it.
To make sure palbociclib is safe for you, tell your doctor if you have:
- liver disease; or
- kidney disease.
Do not use palbociclib if you are pregnant.It could harm the unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 3 weeks after your last dose.
You may need to have a negative pregnancy test before starting this treatment.
It is not known whether palbociclib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
Palbociclib Side Effects
Get emergency medical help if you havesigns of an allergic reaction:hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
- blisters or ulcers in your mouth, red or swollen gums, trouble swallowing;
- low white blood cell counts--fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing;
- low red blood cells (anemia)--pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or
- signs of a blood clot in the lung--chest pain, sudden cough, wheezing, rapid breathing, coughing up blood.
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common side effects may include:
- nausea, vomiting, diarrhea, loss of appetite;
- mouth sores, decreased sense of taste;
- weakness, feeling tired;
- numbness, tingling, or burning pain in your arms, legs, hands or feet;
- abnormal liver function tests;
- cold symptoms such as stuffy nose, sneezing, sore throat;
- nosebleed; or
- dry skin, temporary hair loss.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Grapefruit and grapefruit juice may interact with palbociclib and lead to unwanted side effects.Avoid the use of grapefruit products while taking palbociclib.
Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.
Other drugs may interact with palbociclib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Palbociclib is given in a 28-day treatment cycle, and you may only need to take the medicine during the first 3 weeks of each cycle. Your doctor will determine how long to treat you with palbociclib.
Take with food.
Take the medicine at the same time each day.
Do not crush, chew, break, or open a palbociclib capsule. Swallow it whole.
If you vomit after taking the medicine, wait until the next day to take your next dose.
Do not use a broken or damaged pill.
Palbociclib can lower blood cells that help your body fight infections and help your blood to clot. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often.
Store at room temperature away from moisture and heat.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Skip the missed dose and do not take the medicine again until your next scheduled dose.Do nottake extra medicine to make up the missed dose.
Copyright 1996-2019 Cerner Multum, Inc.
Video: Palbociclib and Ribociclib
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